diff --git a/requirements-dev.in b/requirements-dev.in
index 166016e65..77de63310 100644
--- a/requirements-dev.in
+++ b/requirements-dev.in
@@ -9,4 +9,4 @@ nodeenv
 -r requirements-tests.txt
 
 # === Datadog-specific additions ===
-cryptography==43.0.1  # Must keep pinned for FIPS support (do not sync from upstream)
+cryptography==49.0.0  # Must keep pinned for FIPS support (do not sync from upstream)