Can we utilize the multiple sequence alignment (MSA) or HMM information directly in PISA/DISTAL? Let's say we have 80% ANI between two proteins. Clearly they are homologous (?), then we can build an HMM on the fly for that family and use that to increase sensitivity of subsequent queries?
Can we utilize the multiple sequence alignment (MSA) or HMM information directly in PISA/DISTAL? Let's say we have 80% ANI between two proteins. Clearly they are homologous (?), then we can build an HMM on the fly for that family and use that to increase sensitivity of subsequent queries?