I noticed the difference in the LD scores for the variances of γ and α between MRAPS and XMR. XMR does not adopt the LDSC assumption for the distributions of γ₁, γ₂, and α. Specifically, the LD score does not appear in front of the variance of the joint distribution. Is this a novel design or a typo? If it is a novel design, does it contradict the earlier assumptions in MRAPS? Also, has it been verified how large the impact is between using LD scores and not using them?
I noticed the difference in the LD scores for the variances of γ and α between MRAPS and XMR. XMR does not adopt the LDSC assumption for the distributions of γ₁, γ₂, and α. Specifically, the LD score does not appear in front of the variance of the joint distribution. Is this a novel design or a typo? If it is a novel design, does it contradict the earlier assumptions in MRAPS? Also, has it been verified how large the impact is between using LD scores and not using them?