diff --git a/CHANGELOG.md b/CHANGELOG.md
index 50a1a277..57c5d9f7 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,9 @@ All notable changes to this project will be documented in this file.
 The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/),
 and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.html).
 
+## [14.5.0] - 2026-06-04
+- Add deregister_generic_rpc()
+
 ## [14.5.0] - 2026-06-03
 - Shared awaitable
 
diff --git a/conanfile.py b/conanfile.py
index fd03849f..84ad962a 100644
--- a/conanfile.py
+++ b/conanfile.py
@@ -10,7 +10,7 @@
 
 class SISLConan(ConanFile):
     name = "sisl"
-    version = "14.5.0"
+    version = "14.6.0"
 
     homepage = "https://github.com/eBay/sisl"
     description = "Library for fast data structures, utilities"
diff --git a/include/sisl/grpc/rpc_server.hpp b/include/sisl/grpc/rpc_server.hpp
index 0372fec3..1e967583 100644
--- a/include/sisl/grpc/rpc_server.hpp
+++ b/include/sisl/grpc/rpc_server.hpp
@@ -129,6 +129,11 @@ class GrpcServer : private boost::noncopyable {
     void run_generic_completion_cb(const std::string& rpc_name, boost::intrusive_ptr< GenericRpcData >& rpc_data);
     bool register_async_generic_service();
     bool register_generic_rpc(const std::string& name, const generic_rpc_handler_cb_t& rpc_handler);
+    // Remove a previously registered generic RPC handler so the server stops dispatching it (returns true if an
+    // entry was removed). New calls for `name` get UNIMPLEMENTED via run_generic_handler_cb; this does NOT drain a
+    // handler already executing (run_generic_handler_cb releases the registry lock before invoking the cb), so the
+    // caller must ensure no in-flight handler outlives any state the cb captures.
+    bool deregister_generic_rpc(const std::string& name);
 
 private:
     void handle_rpcs(uint32_t thread_num, const rpc_thread_start_cb_t& thread_start_cb);
diff --git a/src/grpc/rpc_server.cpp b/src/grpc/rpc_server.cpp
index d901cec4..99eec42f 100644
--- a/src/grpc/rpc_server.cpp
+++ b/src/grpc/rpc_server.cpp
@@ -227,6 +227,14 @@ bool GrpcServer::register_generic_rpc(const std::string& name, const generic_rpc
     return true;
 }
 
+bool GrpcServer::deregister_generic_rpc(const std::string& name) {
+    // Drop the handler from the dispatch registry; subsequent run_generic_handler_cb lookups for `name` miss and
+    // return UNIMPLEMENTED. The per-cq GenericRpcData accept slots are generic (not per-method), so they are left
+    // in place to keep serving the remaining registered methods.
+    std::unique_lock< std::shared_mutex > lock(m_generic_rpc_registry_mtx);
+    return m_generic_rpc_registry.erase(name) > 0;
+}
+
 // RPCHelper static methods
 
 bool RPCHelper::has_server_shutdown(const GrpcServer* server) {