diff --git a/packages/dom/src/serialize-pseudo-classes.js b/packages/dom/src/serialize-pseudo-classes.js
index a7ca35069..023804afa 100644
--- a/packages/dom/src/serialize-pseudo-classes.js
+++ b/packages/dom/src/serialize-pseudo-classes.js
@@ -330,10 +330,26 @@ function stylesToCSSText(styles) {
   return decls.join(' ');
 }
 
+// Resolve a nested rule's selector against its parent per CSS Nesting.
+// The CSSOM serializes nested selectors with the implicit nesting selector
+// made explicit, so every nested selector — including each item of a
+// selector list — carries its own `&`. Replacing every `&` with :is(parent)
+// therefore fully scopes the rule. Without this, a bare top-level `&`
+// resolves to :root on engines that support nesting, so component-scoped
+// interactive-state rules leak page-wide (PER-9775). :is(...) preserves the
+// parent's grouping/specificity.
+function resolveNestedSelector(selectorText, parentSelector) {
+  if (!parentSelector) return selectorText;
+  return selectorText.replace(/&/g, `:is(${parentSelector})`);
+}
+
 // Walk a CSSRule list yielding every reachable style rule. Nested rules
 // inside @media/@layer/@supports are emitted with the at-rule prelude
 // preserved as a wrapper string; flat-emitting would drop the guard.
-function walkCSSRules(ruleList) {
+// `parentSelector` carries the enclosing style rule's (already-resolved)
+// selector down through native CSS nesting so `&`-relative children are
+// resolved against it rather than leaking as a bare top-level `&`.
+function walkCSSRules(ruleList, parentSelector = null) {
   const result = [];
   for (let i = 0; i < ruleList.length; i++) {
     const rule = ruleList[i];
@@ -343,7 +359,19 @@ function walkCSSRules(ruleList) {
       const atRulePrelude = conditionText && rule.cssText
         ? rule.cssText.split('{')[0].trim()
         : null;
-      for (const inner of walkCSSRules(rule.cssRules)) {
+      // An at-rule (@media/@layer/@supports) keeps the current parent scope
+      // and is re-applied as a wrapper. A style rule with nested children
+      // (native CSS nesting) becomes the scope for its children — resolve
+      // its own selector against any outer parent first so deeper nesting
+      // composes correctly.
+      // Default to the current scope (also covers at-rules and nested-decl
+      // rules that have no selector of their own). A style rule with nested
+      // children resolves its own selector first and becomes the new scope.
+      let childParent = parentSelector;
+      if (!atRulePrelude && rule.selectorText) {
+        childParent = resolveNestedSelector(rule.selectorText, parentSelector);
+      }
+      for (const inner of walkCSSRules(rule.cssRules, childParent)) {
         if (atRulePrelude && inner.selectorText) {
           result.push({
             selectorText: inner.selectorText,
@@ -358,7 +386,11 @@ function walkCSSRules(ruleList) {
       // Rules without nested cssRules and without selectorText (@font-face,
       // @charset, @counter-style, etc.) are skipped — they can't contain
       // interactive pseudos.
-      result.push({ selectorText: rule.selectorText, style: rule.style, wrapper: null });
+      result.push({
+        selectorText: resolveNestedSelector(rule.selectorText, parentSelector),
+        style: rule.style,
+        wrapper: null
+      });
     }
   }
   return result;
diff --git a/packages/dom/test/serialize-pseudo-classes.test.js b/packages/dom/test/serialize-pseudo-classes.test.js
index febc30d23..ad8cded93 100644
--- a/packages/dom/test/serialize-pseudo-classes.test.js
+++ b/packages/dom/test/serialize-pseudo-classes.test.js
@@ -1793,4 +1793,109 @@ describe('serialize-pseudo-classes', () => {
       expect(s.size).toBe(0);
     });
   });
+
+  // Regression: native CSS nesting (emotion / CSS-in-JS) produces child rules
+  // with `&`-relative selectors. Before the fix, walkCSSRules emitted those
+  // children with the parent selector stripped, so an interactive-pseudo child
+  // like `&:hover` was injected as a bare `&[data-percy-hover]`. A top-level
+  // `&` resolves to :root on engines that support nesting, leaking component
+  // styles to the whole page (blue background, black SVG backgrounds, wrong
+  // button colors).
+  describe('native CSS nesting — parent selector resolution', () => {
+    function nestingCtx() {
+      let ctx = {
+        dom: document,
+        clone: document.implementation.createHTMLDocument('Clone'),
+        warnings: new Set(),
+        cache: new Map(),
+        resources: new Set(),
+        hints: new Set(),
+        shadowRootElements: []
+      };
+      // nosemgrep: javascript.browser.security.insecure-document-method.insecure-document-method
+      ctx.clone.body.innerHTML = document.body.innerHTML;
+      return ctx;
+    }
+
+    function injectedRules() {
+      let style = ctx.clone.querySelector('style[data-percy-interactive-states]');
+      return style ? style.textContent : '';
+    }
+
+    // Confirms the test browser actually parses nesting into nested cssRules;
+    // otherwise these assertions wouldn't exercise the nesting path.
+    function nestingSupported() {
+      for (let sheet of document.styleSheets) {
+        try {
+          for (let rule of sheet.cssRules) {
+            if (rule.cssRules && rule.cssRules.length) return true;
+          }
+        } catch (e) { /* cross-origin */ }
+      }
+      return false;
+    }
+
+    it('scopes a nested &:hover to its parent instead of leaking to :root', () => {
+      withExample(
+        '<style>.cta-card { color: black; &:hover { background-color: blue; } }</style>' +
+        '<button class="cta-card" id="cta">x</button>',
+        { withShadow: false }
+      );
+      expect(nestingSupported()).toBe(true);
+
+      ctx = nestingCtx();
+      serializePseudoClasses(ctx);
+
+      let rules = injectedRules();
+      expect(rules).toContain(':is(.cta-card)[data-percy-hover]');
+      // No bare leading `&` (which would resolve to :root page-wide).
+      expect(rules).not.toMatch(/(^|[\s,{])&/);
+    });
+
+    it('treats an &-less nested selector as a descendant of the parent', () => {
+      withExample(
+        '<style>.menu { a:hover { color: red; } }</style>' +
+        '<nav class="menu"><a href="#" id="lnk">x</a></nav>',
+        { withShadow: false }
+      );
+      expect(nestingSupported()).toBe(true);
+
+      ctx = nestingCtx();
+      serializePseudoClasses(ctx);
+
+      expect(injectedRules()).toContain(':is(.menu) a[data-percy-hover]');
+    });
+
+    it('resolves each part of a nested selector list (top-level comma)', () => {
+      withExample(
+        '<style>.btn { &:hover, &:focus { outline: 1px solid red; } }</style>' +
+        '<button class="btn" id="b1">x</button>',
+        { withShadow: false }
+      );
+      expect(nestingSupported()).toBe(true);
+
+      ctx = nestingCtx();
+      serializePseudoClasses(ctx);
+
+      let rules = injectedRules();
+      expect(rules).toContain(':is(.btn)[data-percy-hover]');
+      expect(rules).toContain(':is(.btn)[data-percy-focus]');
+    });
+
+    it('scopes a complex nested selector, preserving :is() grouping and attributes', () => {
+      withExample(
+        '<style>.box { &:is(.a, .b)[data-role]:hover { color: green; } }</style>' +
+        '<div class="box a" data-role id="bx">x</div>',
+        { withShadow: false }
+      );
+      expect(nestingSupported()).toBe(true);
+
+      ctx = nestingCtx();
+      serializePseudoClasses(ctx);
+
+      // The :is(.a, .b) list and [data-role] survive intact, prefixed by the
+      // resolved parent — emitted as a single rule, not split on the inner comma.
+      expect(injectedRules()).toContain(':is(.box):is(.a, .b)[data-role][data-percy-hover]');
+    });
+  });
 });